Intermediates are chemical compounds formed during the various stages of active pharmaceutical ingredient (API) production. They are essentially the "building blocks" in the multi-step synthesis process that eventually leads to the final API. Intermediates are not the finished product but play a crucial role in ensuring the successful creation of high-quality APIs.
Intermediates are also an important part of the global pharmaceutical supply chain. Many intermediates are manufactured by specialized companies and then sold to API producers, fostering collaboration within the industry. The complexity of these intermediates can vary significantly, depending on the sophistication of the API being synthesized.
| API | Intermediate Name | CAS No. |
|---|---|---|
| Fluconazole | 1-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)ethanone (DFTA) | 873055-58-4 |
|
Voriconazole |
(2R,3S/2S,3R)-3-(5-Fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
|
873055-58-4
|
|
Posaconazole |
(S)-(+)-4-Phenyl-2-oxazolidinone
|
99395-88-7
|
|
Efavirenz |
Cyclopropyl Acetylene
|
6746-94-7
|
|
Valganciclovir Hcl |
N-2-Acetylguanine
|
19962-37-9
|
|
Vildagliptin |
(2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile
|
207557-35-5
|
|
Linagliptin |
(R)-3-(Boc-Amino)piperidine |
309956-78-3
|
|
Imeglimin Hydrochloride |
Imeglimin base |
775351-65-0
|
|
Sitagliptin Phosphate |
Tert-butyl N-[(2R)-4-oxo-4-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-1- |
486460-23-5
|
|
Dapagliflozin |
(3R,4S,5R,6R)-3,4,5-tris(trimethylsilyloxy)-6-[(triMethylsilyloxyMethyl)tetrahydro-2H-pyran-2-one
|
32384-65-9
|
| Losartan Potassium | 1-((2'-[1H-tetrazol-5-yl],1,1'-biphenyl)-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-ylmethanol | 114798-26-4 |
|
Nirmatrelvir |
Methyl(S)-2-[(tert-butoxycarbonyl)amino]-3-((S)-2-oxopyrrolidin-3-yl)propanoate (SM1) |
328086-60-8
|
|
Rivaroxaban |
2-[(2R)-2-hydroxy-3-[4-(3-oxomorpholin-4-yl)phenyl]amino]propyl]-1H-isoindole-1,3(2H)-dione |
446292-07-5
|
|
Tapentadol HCl |
(S)-3-(dimethylamino)-1-(3-methoxyphenyl)-2-methylpropan-1-one |
850222-40-1
|
|
Lamivudine |
(1R,2S,5R)-Menthyl-(2R,5S)-5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-[1,3]oxathiolane-2-carboxylic acid
|
147027-10-9
|
| Emtricitabine | (2R,5S)-5-(4-Amino-5-fluoro-2-oxo-1[2H]-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid,(1R,2S,5R)-5-methyl-2-(1-methylhetyl)cyclohexyl ester | 764659-72-5 |
|
Darunavir / Darunavir Ethanolate |
4-Amino-N-[(2R,3S)-3-amino-2-hydroxy-4-phenylbutyl]-N-isobutylbenzenesulfonamide |
169280-56-2
|
|
Ritonavir |
1-(2-isopropylthiazol-4-yl)-N-methylmethanamine dihydrochloride |
1185167-55-8
|
| Lopinavir |
2-(2,6-dimethylphenoxy)acetic acid (S)-3-methyl-2-(2-oxotetrahydropyrimidin-1(2H)-yl)-butanoic acid |
13335-71-2
192725-50-1 |
|
Raltegravir Potassium |
[1-[4-[[(4-fluorobenzyl)amino]carbonyl]-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidin-2-yl]-1-methylethyl]carbamate
|
518048-02-7
|
|
Abacavir Sulfate |
(1R,4S)-4-amino-2-cyclopentene-1-methanol hydrochloride
|
287717-44-6
|
|
Rilpivirine Hcl |
4-[(4-hydroxy-2-pyrimidinyl)amino]benzonitrile |
189956-45-4
|
|
Tigecycline |
N-tert-Butylglycine HCl
|
6939-23-7 |
| Minoxidil | 4-Chloro-2,6-diaminopyramidine |
156-83-2
|
| Oxcarbazepine | 10-Methoxyiminostilbene |
4698-11-7*
|
|
Isavuconazole |
(2R,3R)-3-(2,5-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyramide
|
368421-58-3
|
| Glycine Derivative | Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-[2-[[[(1-chloroethoxy)carbonyl]Methylamino]-3-pyridinyl]methylester |
338990-31-1
|
|
Tirzepatide |
AEEA-AEEA |
1143516-05-5
|
|
Retatrutide |
Fmoc-L-Lys-[C20-OtBu-Glu(OtBu)-AEEA]-OH |
2612237-97-3 |
| Favipiravir | 2-pyrazinecarboxamide,3,4-dihydro-3-oxo-sodium salt (1:1) |
1237524-82-1
|
|
Bedaquiline Fumarate |
N-(4-Bromo-phenyl)-3-phenyl-propionamide |
316416-27-7 |
